What is “VUS”? VUS stands for variant of unknown significance. VUS means that DNA sequence variation is previously unreported and is of the type which may or may not be causative of the disorder.
Some variations are tightly linked to the disease, and some variations are clearly not linked to the disease. There are still many variants of unknown significance. If a patient has the VUS, clinicians and medical geneticists work together and figure out whether the VUS is associated with the disease or not.
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