Is headache related to Wolfram syndrome? This is a difficult question because most of us experience headache even though we don’t have Wolfram syndrome or other medical conditions. As far as I know, headache may be related to autonomic dysfunction or neuropathy in Wolfram. Some patients experience sharp and stabbing unilateral pain similar to trigeminal neuralgia. A consultation with a neurologist is recommended. Carbamazepine or amitriptyline has been shown to be effective in some patients. Thank you for reading my blogs. I have been doing my best.