OMIM is a continuation of Dr. Victor A. McKusick’s Mendelian Inheritance in Man, which was published through 12 editions, the last in 1998. OMIM is based on the peer-reviewed biomedical literature, and criteria for inclusion of papers continue to evolve. In general, priority for inclusion is given to papers that provide significant insight into the gene-phenotype relationship, expand our understanding of human biology, or contribute to the characterization of a disorder. Information in each OMIM entry is cited, and the full reference is provided. OMIM is biocurated at the McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine.