Looking for disease modifying loci to identify new drug targets

We are looking for disease modifying loci for Wolfram syndrome to identify new drug targets. What are disease modifying loci? These are the genes that may play a role in delaying or accelerating the progression of the disease. In addition to WFS1 or WFS2, it seems like there are genes affecting the manifestations of the disease. If we can identify these genes, we may be able to target the products of these genes to delay the progression. So we are searching for these genes.

Thank you for reading this blog. I hope you will have a wonderful week. I am sending kind thoughts toward you.
Fumi Urano