Wolfram syndrome is often misdiagnosed as Type 1 diabetes. Patients with early-onset diabetes mellitus who are negative for islet autoantibodies and lean may have syndromic monogenic diabetes. Monogenic diabetes genetic testing, including WFS1 gene, should be considered for such patients (https://www.sciencedirect.com/science/article/pii/S2376060522000013?via%3Dihub).