Based on the data we have, we believe that Wolfram syndrome is caused by endoplasmic reticulum dysfunction. Our data also suggest that chronic high glucose exacerbates endoplasmic reticulum dysfunction. Thus, it is very important for our patients to maintain normal glucose levels to delay the progression. This should be discussed with your physician, nurse and dietician.
Thank you for reading this. I hope you have a wonderful weekend.
Kindly,
Fumi Urano